from RotTable import RotTable from Traj3D import Traj3D import numpy as np from math import sqrt, inf from random import random, randrange P1 = 0.015 class Individu(): def __init__(self, table): self.table = table lineList = [line.rstrip('\n') for line in open("plasmid_8k.fasta")] self.brin = ''.join(lineList[1:]) #self.brin = "AAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCCAGTAAACGAAAAAACCGCCTGGGGAGGCGGTTTAGTCGAA" self.score = self.evaluate() def evaluate(self): traj = Traj3D() numb_ajout = 3 fisrt_seq = self.brin[0:numb_ajout] last_seq = self.brin[-numb_ajout:] traj.compute(last_seq + self.brin + fisrt_seq, self.table) traj_array = np.array(traj.getTraj()) list_distance = [] for i in range(numb_ajout): first_nuc_coordonate = traj_array[numb_ajout+i, 0:3] first_nuc_coordonate_compute = traj_array[-(numb_ajout-i), 0:3] last_nuc_coordonate = traj_array[-(2*numb_ajout-i), 0:3] last_nuc_coordonate_compute = traj_array[i, 0:3] distance_first_nuc = np.linalg.norm(first_nuc_coordonate - first_nuc_coordonate_compute, ord=2) distance_last_nuc = np.linalg.norm(last_nuc_coordonate - last_nuc_coordonate_compute, ord=2) list_distance += [distance_first_nuc, distance_last_nuc] self.score = 1/max(list_distance) return 1/max(list_distance) def mutation_with_numbers(self, proba = P1): table_rotations = self.table.rot_table number_of_mutations = 5 for i in range(0,number_of_mutations): tir = random() if tir < proba : doubletNumber = randrange(0,8) counter = 0 for doublet in table_rotations: if counter==doubletNumber: break counter+=1 for coord in range(3): table_rotations[doublet][coord] =np.random.uniform(low = self.table.orta()[doublet][coord] - self.table.orta()[doublet][coord + 3], high = self.table.orta()[doublet][coord] + self.table.orta()[doublet][coord + 3]) doublet2 = self.table.corr()[doublet] if coord == 0 or coord == 1 : table_rotations[doublet2][coord] = table_rotations[doublet][coord] else : #sur l'axe z il y a un moins table_rotations[doublet2][coord] = - table_rotations[doublet][coord] def mutation(self, proba = P1): table_rotations = self.table.rot_table for doublet in table_rotations : for coord in range(3): tir = random() if tir < proba : table_rotations[doublet][coord] =np.random.uniform(low = self.table.orta()[doublet][coord] - self.table.orta()[doublet][coord + 3], high = self.table.orta()[doublet][coord] + self.table.orta()[doublet][coord + 3]) doublet2 = self.table.corr()[doublet] if coord == 0 or coord == 1 : table_rotations[doublet2][coord] = table_rotations[doublet][coord] else : #sur l'axe z il y a un moins table_rotations[doublet2][coord] = - table_rotations[doublet][coord] # individu1 = Individu(RotTable()) # print(individu1.table.rot_table) # individu1.mutation() # table = RotTable() # test = Individu(table) # test.evaluate("AAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCCAGTAAACGAAAAAACCGCCTGGGGAGGCGGTTTAGTCGAA") # print(test.score) # qqun=Individu(RotTable()) # qqun.table.rot_table={'AA': [35.576558502141, 7.433901511509349, -154], 'AC': [33.22048222654215, 5.25191751302917, 143], 'AG': [26.446029097301288, 6.052240462237622, -2], 'AT': [30.47045254036881, 1.333716025628036, 0], 'CA': [34.00734209585039, 33.70710613604862, -64], 'CC': [33.61019622767888, 3.713127032109607, -57], 'CG': [29.664061041382677, 6.725155507162601, 0], 'CT': [26.446029097301288, 6.052240462237622, 2], 'GA': [36.655773481637176, 10.45337581740701, 120], 'GC': [42.26984493493484, 3.5310453395352823, 180], 'GG': [33.61019622767888, 3.713127032109607, -57], 'GT': [33.22048222654215, 5.25191751302917, 143], 'TA': [36.951508786388914, -2.5174751178033303, 0], 'TC': [36.655773481637176, 10.45337581740701, -120], 'TG': [34.00734209585039, 33.70710613604862, -64], 'TT': [35.576558502141, 7.433901511509349, -154]} # qqun.evaluate("AAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCCAGTAAACGAAAAAACCGCCTGGGGAGGCGGTTTAGTCGAA") # print(qqun.score)